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Ten Under 10: Highlighting Our Profession
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Emergency Management of Dental Traumas
MDS Member Researcher(s) Include: Isabelle Chase, DDS
One of the most common oral injuries that occur in the child
or adolescent involves the avulsed tooth.
There has been an increase in the numbers of these injuries worldwide to
sports activities, and some of the newer recreational activities (skate-boarding,
trampoline jumping etc). Worldwide there are 5.8 million cases of trauma per
year. Male patients are 2/3 of victims, hospitalizations
have increased thirty-fold and emergency room visits have increased 300-fold.
Although this is a common problem for all types of dental
practices, many injuries occur after hours or on weekends when most dental
practices are shut. Therefore many cases
present to the Emergency Room, where there are no dental staff present. It is incumbent on the medical staff to have
an understanding on how to diagnose dental injuries, manage them and make the
appropriate referral to a dental practitioner.
There are several injuries that can occur to the oral area
(soft tissue, fractures to the teeth, luxations, avulsions), this first
resource will focus on how to deal with avulsions. An avulsion of a tooth
occurs when the tooth gets knocked out the socket. Typically this occurs to the central
incisors, and the maxillary teeth are affected more than the mandibular
teeth. The objectives of the resources
developed (powerpoint, problem based learning case and video) are to teach the
student/practitioner how to provide first-line management for stabilizing oral
injuries, specifically the avulsed tooth, to the point of referral.
Full Article: MedEdPORTAL; 2013
Hospitalizations primarily attributed to dental conditions in the United States in 2008
MDS Member Researcher(s) Include: Romesh Nalliah, DDS
Objective - The objective of this study was to provide estimates of hospitalizations attributed to oral health related conditions
in the United States (US).
Study Design - The nationwide inpatient sample (NIS) of the Healthcare Cost and Utilization Project (HCUP) for 2008 was used. Hospital admissions with a primary diagnosis of dental/oral health–related conditions were identified using ICD-9-CM diagnosis codes.
Results - A total of 50,658 hospital admissions were primarily attributed to oral health–related conditions in 2008. Total US
hospitalization charges were $1.218 billion. Total US hospitalization days were 174,496 days.
Conclusions - The current study examines outcomes in patients hospitalized primarily for dental/oral health–related conditions. Of 39,885,120 hospitalizations that occurred in the US, a total of 50,658 (1.27%) were primarily attributed to dental-related conditions. Substantial resources are spent in treating dental-related conditions in hospital settings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:333-337)
Full Article: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2012 Sept.
Whole-saliva Proteolysis and Its Impact on Salivary Diagnostics
MDS Member Researcher(s) Include: Frank Oppenheim, DMD, PhD
Abstract: There is growing interest in the use of human whole saliva for diagnostics and disease monitoring as an alternative to blood samples. In contrast to blood, whole saliva is a non-sterile body fluid. Proper handling and storage are required to preserve the integrity of potential biomarkers. We investigated salivary autoproteolytic degradation using a variety of approaches. We determined inhibition of protease activities by monitoring the endogenous proteome. In addition, the stability of highly protease-susceptible proteins—histatin 5, statherin, and PRP1—was assessed. Experimental variables included (a) protease inhibitors, (b) salivary pH, (c) incubation temperatures, and (d) sample heating. A cocktail containing AEBSF, aprotinin, pancreatic trypsin inhibitor, leupeptin, antipain, and EDTA could not prevent histatin 5, statherin, or PRP1 degradation in whole saliva. Among the other treatments evaluated, short-term storage of freshly collected samples on ice was effective without interfering with the chemistry of the proteome. In conclusion, whole saliva contains a unique mixture of enzymes as evidenced from their resilience to protease inhibition. Analytical evidence on protein stability is needed to ensure the validity of salivary biomarker study outcomes. Analysis of the data presented will provide help and guidance for the
use of saliva samples for diagnostic purposes.
Full Article: Journal of Dental Research 2011 Sept 13.